pathology of lung cancer  

definition

- definiton of atypical adenomatous hyperplasia

- definition of mucinous AIS

- definition of mucinous MIA

- definition of adenocarcinoma

- definition of lepidic adenocarcinoma

- definition of acinar predominant adenocarcinoma

- definition of papillary predominant adenocarcinoma

- definition of solid predominant adenocarcinoma

definition of atypical adenomatous hyperplasia

 

definition of mucinous AIS

 

definition of mucinous MIA


 

definition of adenocarcinoma

 

definition of lepidic adenocarcinoma

 

definition of acinar predominant adenocarcinoma

 

definition of papillary predominant adenocarcinoma

 

definition of solid predominant adenocarcinoma

cytology staining

- cell type แต่ละชนิดย้อมติดสิอะไรบ้าง

cell type แต่ละชนิดย้อมติดสิอะไรบ้าง

- adenocarcinoma

- squamous cell carcinoma

- neuorendocrine morphology

adenocarcinoma

- architecture features of adenocarcinoma มีอะไรบ้าง

- subtype of adenocarcinoma

- subtype progression of adenocarcinoma

architecture features of adenocarcinoma มีอะไรบ้าง

 

subtype of adenocarcinoma

- preinvasive lesions

- minimally invasive adenocarcinoma

- invasive adenocarcinoma

- variants of invasive adenocarcinoma

 

subtype progression of adenocarcinoma

gross pathology

- invasive adenocarcinoma

- colloid adenocarcinoma

- squamous cell carcinoma

- small cell carcinoma

invasive adenocarcinoma

- peripheral adenocarcinoma often puckers overlying visceral pleura

** pleural surface

** cut surface

 

colloid adenocarcinoma

- the cut surface reveals well-circumscribed, gelatinous tumor

 

sqaumous cell carcinoma

- centrally located squamous cell carcinoma with the tumor presents an endobronchial mass infiltrating to a hilar lymph node

 

small cell carcinoma

- the tumor is located in the central area and directly invades the hilar soft part and lymph nodes with metastases into mediastinal lymph nodes

histology

- adenocarcinoma, lepidic pattern

- invasive adenocarcinoma, acinar pattern

- invasive adenocarcinoma, papillary pattern

- invasive adenocarcinoma, micropapillary pattern

- sqaumous cell carcinoma

- basaloid squamous cell carcinoma

- adenosquamous carcinoma

- NUT- carcinoma

- diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNEC)

- large-cell neuroendocrine tumor

- small cell lung carcinoma

- combined small cell carcinoma

- visceral pleural invasion

adenocarcinoma, lepidic pattern

- alveolar walls are lined by uniform, cuboidal tumor cells with mild-to-moderate atypia

- tumor cells with mucin-rich cytoplasm proliferate on the alveolar wall with extracellular mucin

 

invasive adenocarcinoma, acinar pattern

- fused, angulated, or cribiform glands consist of cuboidal tumor cells

 

invasive adenocarcinoma, papillary pattern

- the structures are supported by fibrovascular cores with complicated secondary and tertiary branches and tufts

 

invasive adenocarcinoma, micropapillary pattern

- tumor cell clusters show small tufts without fibrovascular cores

 

high-grade fetal adenocarcinoma

- pseudostratified columnar epithelium consists of cells with the uniform oval nuclei and glycogen-rich clear cytoplasm

 

sqaumous cell carcinoma

- keratinizing squamous cell carcinoma with tumor cells are characterized by keratinization and intracellular bridge formation

 

basaloid sqaumous cell carcinoma

- a tumor nest is composed of cuboidal and fusiform cancer cells with the scant cytoplasm, which demonstrate peripheral palisading

 

adenosquamous carcinoma

- both squamous differentiation (left upper) and glandular differentiationi (right lower)

 

NUT-carcinoma

- poorly differentiated tumor cells infiltrate into the bronchial wall

 

diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)

- the tumor cell shows central fibrous area and ragged, infiltrating edge

 

large-cell neuroendocrine tumor

- the tumor has an NE morphology (organoid pattern): tumor cells show a lower nuclear-to-cytoplasmic ratio and prominent nucleoli

compared to small cell carcinoma

 

small cell lung carcinoma

- the tumor is composed of sheets and nests of tumor cells with a high nuclear-to-cytoplasmic ratio demonstrating high mitotic activity

 

combined small cell carcinoma

- both small cell carcinoma area (left upper) and adenocarcinoma area (right lower)

 

visceral pleural invasion

- tumor cells invade beyond teh elastic layer (PL1)

- tumor cells invade the pleural surface (PL2) with orange liens and arrows indicate the elastic layer and tumor cells

histology (papanicolaou preparation)

- adenocarcinoma

- squamous cell carcinoma

- small cell lung carcinoma

adenocarcinoma

- a flat sheet of tumor cells with the hyperchromatic muclei and conspicuous nucleoli

 

squamous cell carcinoma

- a brushing smear shows tumor cells of different sizes with the orange cytoplasm indicating keratinization

 

small cell lung carcinoma

- tumor cells have a high nuclear-to-cytoplasmic ratio

- the nuclei are characterized by delicate chromatin without the prominent nucleoli

- crush artifact shows a stringy nucleus characteristic for small cell carcinoma